An efficient and green synthesis of 3- phenyl-1H-pyrazolo [3, 4-d] pyrimidine derivatives

  • School of advanced sciences, Vellore Institute of Technology, Vellore-632014, Tamil Nadu, India.
  • Department of Chemistry, S.B.V.R.Degree College, Badvel-516227, A.P, India
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An efficient and green method for the preparation of 3- phenyl-1H-pyrazolo [3, 4-d] pyrimidine derivatives (3a-r) in minutes of time with high yields is accomplished by the mixture of 3-iodo-1H-pyrazolo[3,4-d]pyrimidine pyrazole (1) and various aryl boronic acids (2a-m) at 100°C under microwave irradiation in the presence of Pyridine-Pyrazole/ Pd (II) complex and aqueous medium. The catalyst recovered, reused several times and air-stable.

[Bijivemula. N. Reddy, M. Subbareddy, P.Srinivasulureddy and Madhvesh Pathak (2016); An efficient and green synthesis of 3- phenyl-1H-pyrazolo [3, 4-d] pyrimidine derivatives Int. J. of Adv. Res. 4 (Jan). 1581-1586] (ISSN 2320-5407). www.journalijar.com

madhveshpathak

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